Cable & Wireless and +Móvil cover cities and Pan-American Highway on 4G; Darién gap approaches and remote San Blas cays fade between islands. Canal-zone tourism strips stay well served. Check the network list above for Panama before you fly; it shows what is available right now, including options such as Cable & Wireless, Telefonica.
There is no complicated Panama-only product to learn. NXTL is one global eSIM: the same profile you might use elsewhere works here on Cable & Wireless, Telefonica when listed. Land, turn data on, and go — rates for Panama are shown live on this page because they can change.
Prepaid SIMs are sold at the airport and city kiosks with passport registration. Island travellers top up before water-taxi legs to Bocas. That still makes sense if you will live in Panama City for months and need local calls. For a holiday or short work trip, most people only need data — and NXTL gives you that without the desk stop: install at home, keep your usual number for calls and bank texts, pay only for the gigabytes you use.
If Panama is one stop on a longer route, NXTL is built for that. Use data around Panama City and Bocas del Toro, then keep the same balance wherever NXTL has coverage next. You are not locked into a single-country tourist pack.
San Blas Guna Yala trips use open canoe transfers where signal disappears until you reach the next coconut-island camp. NXTL is built for that kind of Panama trip: data when you need it, without buying a new pack for every change of plan.